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Download dvdrip (dororo 2007 dvdrip download movie)Effects of 2,5- and 2,6-dimethoxy substitution on the in vivo anticonvulsant activity of 2-amino-3-chlorophenyl mercaptoacetamide.
2,5- and 2,6-Diarylpropylamine derivatives with mercaptoacetamide at the 2-position of the aryl ring were synthesized, and their in vivo anticonvulsant activities against generalized tonic-clonic (MES) and maximal electroshock (MESmax) seizures were examined. Among the compounds, 2,5-diphenyl propylamine (7b) showed the most potent anticonvulsant activity, with ED50 values against MES and MESmax of 29.3 and 28.7 mg/kg, respectively. Structural changes of the 2-substituent from 2-chloro to 2-mercapto were found to be more effective than those with substitutions of 2-fluoro or 3-fluoro.Multi-faceted roles of doublecortin in neurogenesis and neuronal migration.
Doublecortin is a microtubule-associated protein (MAP) that has been identified as the main protein expressed in early-born migrating neurons. However, although the phenotype of doublecortin null mice is well characterized, a clear link between doublecortin and MAPs is still missing. Recently, it was shown that doublecortin binds directly to tubulin and to dynein, suggesting that it could act as a linker or microtubule stabilizer. Another intriguing finding is that the homolog of doublecortin is also present in early-born neurons of invertebrates such as sea urchin, suggesting a conserved role of doublecortin throughout evolution. In this study, we have explored the function of doublecortin in the cortex of the zebrafish (Danio rerio), a simple vertebrate organism with a better resolution of neuronal migration pattern in comparison to the rodent model system. We show that doublecortin is first expressed in intermediate progenitors and that doublecortin null mutants display an abnormal thickening of the cortical plate and a decreased proportion of neurons born in the subventricular/ventricular zones. We also demonstrate the presence of doublecortin in both immature and mature neurons and in d
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